Introduction: Juvenile nasopharyngeal angiofibroma is a rare, highly .. Luiz A CR, Romualdo S LT, Fava A S. Angiofibroma nasofaríngeo: revisão de literatura. Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor arising predominantly in the nasopharynx of adolescent males. It is an aggressive. Juvenile nasopharyngeal angiofibromas (JNA) are a rare benign but locally aggressive vascular tumor. Epidemiology Juvenile nasopharyngeal angiofibromas.

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Imaging plays an important role in diagnosis, as biopsies should be avoided due to the risk of brisk hemorrhage, as well as staging. Of the 20 patients, 3 had surgery by combined approaches conventional angiodibroma endoscopicincluding 1 patient with a Fisch IIIA tumor who was treated by the Caldwell-Luc expanded technique and endoscopic surgery, 1 patient with a Fisch IIIA tumor who was treated by the degloving mid-facial technique and endoscopic surgery, and 1 with a Fisch IV tumor who was treated by the degloving mid-facial technique associated with craniotomy and endoscopic surgery.

The hormonal influence in Nawofaringeo remains controversial. The pathogenesis remains controversial, but some theories have been proposed, such as congenital theory, the hormonal, vascular and genetic 2,3, Seventeen patients nasofarinego clamping of the external carotids and tumor embolization.

Recurrence in juvenile angiofibroma. Edit article Share article View revision history. Immunolocalization of activated transforming growth factor beta 1 in juvenile nasopharyngeal angiofibroma. These discrepancies may be due to the monoclonal antibodies nssofaringeo detect only alpha-ER and not the beta ER protein.

Juvenile nasopharyngeal angiofibroma

From a triangular region formed by the foramen ovale, a round and lacerated tumor may reach the middle fossa, migrating to the parasellar region and remaining generally extradual and lateral to the cavernous sinus. CT is particularly useful at delineating bony changes.

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A retrospective case study of five cases of NAJ underwent surgery solely with endoscopic technique of two surgeons. Loss of expression of GSTM 1 null genotype is seen in jasofaringeo tumor. Angiofibroma — rewiew of cases. The first description of an endoscopic resection was published in In this study, we have described our experience in treating 20 patients with nasopharyngeal angiofibromas in the Department of Otorhinolaryngology.

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Kaklamani VG, Pasche B.

They may extend towards the nasopharynx, which includes the maxillary, ethmoid, and sphenoid sinuses. Sanchez de Guzman G. So there is need for further action to claim that this technique has a low recurrence rate, since the recurrence is probably related to incomplete resection the initial tumor. Sign up for nasofaringwo Email Newsletters. Nasopharyngeal angiofibroma[TI] free full text[sb]. It is an aggressive neoplasm and shows a propensity for destructive local spread often extending to the base of the skull and into the cranium.

All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. The expression increase was qualified by increased levels of mRNA and by nasfaringeo protooncogene’s protein Several classification methods have been utilized to stage tumors and assist in choosing the appropriate treatment.

Endoscopic surgery is less invasive than angiofiroma surgery, causing less damage to the patient.

Juvenile nasopharyngeal angiofibroma

Although nasal endoscopic surgery is safe, rapid, and effective, studies are needed to assess the importance of preoperative embolization and clamping of the external carotid artery in reducing intraoperative bleeding. We also found that patients who underwent clamping of the external carotid artery and angiofubroma showed less intraoperative bleeding than patients who underwent embolization alone.

Over the years the access route for the treatment of NAJ has been wngiofibroma with the aim of developing techniques with lower morbidity and lower incidence of recurrence. A comparative study of surgical approches. However, their unique characteristics indicate that the growing factors involved are part of a complex interactions net, which includes cytokines, hormones and other mediators.

By using this site, you agree to the Terms of Use and Privacy Policy. Typically a lobulated non-encapsulated soft tissue mass is demonstrated centred on the sphenopalatine foramen which is often widened and usually bowing the posterior nasofaringei of the maxillary antrum anteriorly. Endoscopic Ressection of Juvenile Angiofibroma: Expression of GSTM1 in angiofibromas. This may have been due to their relatively early diagnosis, when tumors are found smaller and easier to remove completely, as well as due to the use of endoscopic surgery, which assists in controlling tumor removal, including more accurate examinations of the spaces previously occupied by the tumor.

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Laterally, these tumors may extend to and fill the pterygomaxillary fossa, causing the posterior wall of the maxillary sinus to bulge and eroding the pterygoid plate. Received Jul 15; Accepted Jun 1. The other 17 patients underwent endoscopic surgery alone. Aromatase may play a critical role in the pathogenesis of juvenile nasopharyngeal angiofibroma. The encounter of two copies of AR gene in JNA cells cores, along with the presence of AR, remarks the importance of androgen stimulation in this tumor pathogenesis.

Seventeen patients required clamping of the external carotids and angiofirboma embolization. Several reports suggest that JNA regresses over time. See staging of juvenile nasopharyngeal angiofibromas.

Nasopharyngeal angiofibroma: our experience and literature review

Another recent study of Schlauder et al suggests that the enzyme aromatase is responsible for local conversion of androgens to estrogens, which in turn relates to the role of estrogen receptors in tumor growth The histologic origin of JNA involves vascular endothelial cells or fibroblasts.

The color depends on the vascular component and may vary from pale white in less vascular lesions to a pink and wine colored mass in highly vascularized ones. Molecular pathogenesis of juvenile nasopharyngeal angiofibroma in Brazilian patients. Overlying mucosa appeared normal.

Surgical methods in all patients were based on Fisch classifications.