THE DIFFERENT KINDS OF PRODRUGS A. Defi nitions and classifi cations B. The carrier prodrug principle C. The bioprecursor-prodrug principle D. Other. Bioprecursor Prodrugs. Phosphorylation example –. Bioprecursor Prodrugs. We have already seen 2 examples of this: Sulfasalazine – an azo compound. Bioprecursor Prodrugs: Molecular Modification of the Active Principle Keywords: Bioprecursor prodrugs, active metabolites, oxidative activation, glucuronic.

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Disposition of Chemical Compounds. Oxidative Activation P c. Download ppt “Bioprecursor Prodrugs”. Examples of Carrier-linked Bipartate Prodrugs 4. About project SlidePlayer Terms of Service.

Disposition of Chemical Compounds. OK Is the passage of drug from its site of administration to its site of action through cell membranes. Understand how a drug candidate can be modified to generate a prodrug 3. N-Oxidation pralidoxime acetylcholine esterase activator e.

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The presentation bioprecrsor successfully added In Your Favorites. If it were nonspecific, then having the drug administered could cause unwanted side effects or toxicity before even reaching its target. If you wish to download it, please recommend it to your friends in any social system. Disulfide reduction thiamin tetrahydrofurfuryl disulfide thiamin 3. My presentations Profile Feedback Log out. Enter the body by crossing barriers Distributed by the blood to the site of action Biotransform.

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Phenyl carbamates are rapidly cleaved by plasma enzymes although simple carbamates are generally too stable to hydrolysis.

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Bioprecursor prodrugs: molecular modification of the active principle.

WordPress Embed Customize Embed. Enzymes — not just your run of the mill protein! Share buttons are a little bit lower.

Happiness for me is largely a matter of digestion -Lin Yutang. If you bioprecursoor to download it, please recommend it to your friends in any social system. Published by Aubrey Johnston Modified over 3 years ago.

Bioprecursor Prodrugs

Registration Forgot your password? Protect a non-specific biological environment from a drug Protect a drug from a non-specific biological environment Especially evaluated for drugs with a narrow therapeutic window especially anti-cancer agents. Feedback Privacy Policy Feedback. Protect a non-specific biological environment from a drug Protect a drug from a non-specific biological environment Especially evaluated for drugs with a narrow therapeutic window especially anti-cancer agents.

BillJames on May 10, Examples of Carrier-linked Bipartate Prodrugs 3. Auth with social network: Prodrugs to encourage patient acceptance clindamycin antibacterial. What the body does to the drug? About project SlidePlayer Terms of Service. Why have such prodrugs if they are not utilised for the purpose of increasing the rate of transportation across the cell membrane?

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Cookies help us provide you a better browsing experience. Azo reduction prontosil sulfanilamide b. You do not have the permission to booprecursor this presentation.

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Sum total of ALL chemical reactions in a living organism Metabolism is about the energy balance in cells, production. Methenamine the lower the pH, the faster the rate of formaldehyde formed blood pH 7. Automatically changes to Flash or biporecursor embed.

Know some examples of currently used prodrugs PowerPoint Presentation: