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Journal of Natural Medicines [03 Sep65 1: Abstract Ginkgo biloba, an herbal medication, is capable of lowering glucose, fat, and lipid peroxide in diabetic patients. In the current study, we tested the hypothesis that Ginkgo leo extract GBE prevented hyperinsulinism-induced glucose intolerance in hepatocytes. We investigated the effects of GBE on glucose consumption, glucokinase activity, and mRNA levels of key genes in glucose metabolism and the insulin signaling pathway.

To better show its efficacy, we included a control group that was treated with rosiglitazone, 1141 type of thiazolidinedione TZD. The data indicated that GBE repressed glucose uptake under normal conditions, while it dramatically improved glucose tolerance under insulin-resistant conditions. Furthermore, after analyzing gene expression, we suggest that GBE chiefly exerts its effects by stimulating IRS-2 transcription.

It should be noted that, unlike rosiglitazone, GBE did 1118 stimulate excessive glucose uptake as it improved glucose tolerance. It is said that GBE treatment could avoid drug-induced obesity.

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Our data suggest that GBE has the potential to prevent insulin resistance and is a promising anti-diabetic drug. Read Article at publisher’s site. How does Europe PMC derive its citations network? CitePeer Related Articles http: Gene Ontology GO Terms.